2024
Astrocyte glucocorticoid receptors mediate sex-specific changes in activity following stress.
Depaauw-Holt L.R., Hamane S., Peyrard S., Rogers B., Fulton S., Bosson A., Murphy-Royal C.
Preprint on bioRxiv - doi: doi.org/10.1101/2024.09.17.613499
Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation.
Guayasamin M*, Depaauw-Holt L.R.*, Adedipe I.I.*, Ghenissa O, Vaugeois J, Duquenne M, Rogers B, Latraverse-Arquilla J, Peyrard S, Bosson A, Murphy-Royal C. *co-first authors
eLife
Microglial engulfing of glutamatergic inputs and diminished excitability of D1 medium spiny neurons of the nucleus accumbens by peripheral inflammatory insult
Nakajima S, Kabahizi A, Aubailly S, Naili-Douaouda S, Tomita A, Bosson A, Murphy-Royal C, Fulton S
Preprint on bioRxiv - doi: doi.org/10.1101/2024.12.02.625901
Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis
Manceau R, Majeur D, Cherian C, Miller C, Wat L, Fisher J, Labarre A, Hollman S, Prakash S, Audet S, Chao C, Depaauw-Holt L, Rogers B, Bosson A, Xi J, Callow C, Yoosefi N, Shahraki N, Xia Y, Hui A, VanderZwaag J, Bouyakdan K, Rodaros D, Kotchetkov P, Daneault C, Fallahpour G, Tetreault M, Tremblay M-E, Ruiz M, Lacoste B, Parker A, Murphy-Royal C, Huan T, Fulton S, Rideout E, and Alquier T.
Preprint on bioRxiv - doi: doi.org/10.1101/2024.09.19.613929
2023
A Conceptual Framework for Astrocyte Function.
Murphy-Royal C, Ching S, Papouin T.
Nature Neuroscience
2021
A genetically encoded fluorescent biosensor for extracellular L-lactate.
Nasu Y, Murphy-Royal C, Wen Y, Haidey J, Molina MRS, Hughes TE, Aggarwal A, Zhang S, Kamijo Y, Paquet ME, Podgorski K, Drobizhev M, Bains JS, Lemieux MJ, Gordon GR, Campbell RE.
Nature Communications
Obesity-induced astrocyte dysfunction impairs heterosynaptic plasticity in the orbitofrontal cortex.
Lau BK, Murphy-Royal C, Kaur M, Qiao M, Bains JS, Gordon GR, Borgland SL.
Cell Reports
2020
Stress gates an astrocytic energy reservoir to impair synaptic plasticity.
Murphy-Royal C, Johnston AD, Boyce AK, Diaz-Castro B, Zhang O, Institoris I, Peringod G, Thompson R, Khakh BS, Bains JS, Gordon GR.
Nature Communications
Featured in Editor’s highlights of 2020 in Nature Communications - From Brain to Behaviour
Whole brain irradiation in mice causes long-term impairment in astrocytic calcium signaling but preserves astrocyte-astrocyte coupling.
Institoris A, Murphy-Royal C, Tarantini S, Yabluchanskiy, Haidey JN, Csiszar A, Ungvari Z, Gordon GR.
Geroscience
2019
Stress‐induced structural and functional modifications of astrocytes.
Murphy-Royal C, Gordon GR, Bains JS.
Glia
2018
Cholecystokinin Switches the Plasticity of GABA Synapses in the Dorsomedial Hypothalamus via Astrocytic ATP Release.
Crosby KM, Murphy-Royal C, Wilson SA, Gordon GR, Bains JS, Pittman QJ.
Journal of Neuroscience
Is the threshold for astrocyte activation central to the Astrocyte-Neuron Lactate Shuttle?Murphy-Royal C & Gordon GR.
Journal of Physiology
Link to our commentary. Full ‘CrossTalk’ debate
2017
Steady-state free Ca2+ in astrocytes is decreased by experience and impacts arteriole tone.
Mehina EMF, Murphy-Royal C, Gordon GR.
Journal of Neuroscience
Dynamics of surface neurotransmitter receptors and transporters in glial cells: single molecule insights.
Ciappelloni S, Murphy-Royal C, Dupuis JP, Oliet SHR, Groc L.
Cell Calcium
Astroglial glutamate transporters in the brain: regulating neurotransmitter homeostasis and synaptic transmission.
Murphy-Royal C, Dupuis J, Groc L, Oliet SHR.
Journal of Neuroscience Research
2015
Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission.
Murphy-Royal C, Dupuis JP, Varela JA, Panatier A, Pinson B, Baufreton J, Groc L, Oliet SH.
Nature Neuroscience
News & Views - Mobile binding sites regulate glutamate clearance Link