2025
Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation.
Guayasamin M*, Depaauw-Holt L.R.*, Adedipe I.I.*, Ghenissa O, Vaugeois J, Duquenne M, Rogers B, Latraverse-Arquilla J, Peyrard S, Bosson A, Murphy-Royal C. *co-first authors
eLife doi: doi.org/10.7554/eLife.99988.3
2024
Astrocyte glucocorticoid receptors mediate sex-specific changes in activity following stress.
Depaauw-Holt L.R., Hamane S., Peyrard S., Rogers B., Fulton S., Bosson A., Murphy-Royal C.
Preprint on bioRxiv - doi: doi.org/10.1101/2024.09.17.613499
Microglial engulfing of glutamatergic inputs and diminished excitability of D1 medium spiny neurons of the nucleus accumbens by peripheral inflammatory insult
Nakajima S, Kabahizi A, Aubailly S, Naili-Douaouda S, Tomita A, Bosson A, Murphy-Royal C, Fulton S
Preprint on bioRxiv - doi: doi.org/10.1101/2024.12.02.625901
Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis
Manceau R, Majeur D, Cherian C, Miller C, Wat L, Fisher J, Labarre A, Hollman S, Prakash S, Audet S, Chao C, Depaauw-Holt L, Rogers B, Bosson A, Xi J, Callow C, Yoosefi N, Shahraki N, Xia Y, Hui A, VanderZwaag J, Bouyakdan K, Rodaros D, Kotchetkov P, Daneault C, Fallahpour G, Tetreault M, Tremblay M-E, Ruiz M, Lacoste B, Parker A, Murphy-Royal C, Huan T, Fulton S, Rideout E, and Alquier T.
Preprint on bioRxiv - doi: doi.org/10.1101/2024.09.19.613929
2023
A Conceptual Framework for Astrocyte Function
Murphy-Royal C, Ching S, Papouin T.
Nature Neuroscience doi: doi.org/10.1038/s41593-023-01448-8
2021
A genetically encoded fluorescent biosensor for extracellular L-lactate
Nasu Y, Murphy-Royal C, Wen Y, Haidey J, Molina MRS, Hughes TE, Aggarwal A, Zhang S, Kamijo Y, Paquet ME, Podgorski K, Drobizhev M, Bains JS, Lemieux MJ, Gordon GR, Campbell RE.
Nature Communications doi: doi.org/10.1038/s41467-021-27332-2
Obesity-induced astrocyte dysfunction impairs heterosynaptic plasticity in the orbitofrontal cortex
Lau BK, Murphy-Royal C, Kaur M, Qiao M, Bains JS, Gordon GR, Borgland SL.
Cell Reports doi: doi.org/10.1016/j.celrep.2021.109563
2020
Stress gates an astrocytic energy reservoir to impair synaptic plasticity
Murphy-Royal C, Johnston AD, Boyce AK, Diaz-Castro B, Zhang O, Institoris I, Peringod G, Thompson R, Khakh BS, Bains JS, Gordon GR.
Nature Communications doi: doi.org/10.1038/s41467-020-15778-9
Featured in Editor’s highlights of 2020 in Nature Communications - From Brain to Behaviour
Whole brain irradiation in mice causes long-term impairment in astrocytic calcium signaling but preserves astrocyte-astrocyte coupling
Institoris A, Murphy-Royal C, Tarantini S, Yabluchanskiy, Haidey JN, Csiszar A, Ungvari Z, Gordon GR.
Geroscience doi: doi.org/10.1007/s11357-020-00289-8
2019
Stress‐induced structural and functional modifications of astrocytes
Murphy-Royal C, Gordon GR, Bains JS.
Glia doi: doi.org/10.1002/glia.23610
2018
Cholecystokinin Switches the Plasticity of GABA Synapses in the Dorsomedial Hypothalamus via Astrocytic ATP Release
Crosby KM, Murphy-Royal C, Wilson SA, Gordon GR, Bains JS, Pittman QJ.
Journal of Neuroscience doi: doi.org/10.1523/JNEUROSCI.0569-18.2018
Is the threshold for astrocyte activation central to the Astrocyte-Neuron Lactate Shuttle?Murphy-Royal C & Gordon GR.
Journal of Physiology
Link to our commentary. Full ‘CrossTalk’ debate
2017
Steady-state free Ca2+ in astrocytes is decreased by experience and impacts arteriole tone
Mehina EMF, Murphy-Royal C, Gordon GR.
Journal of Neuroscience doi: doi.org/10.1523/JNEUROSCI.0239-17.2017
Dynamics of surface neurotransmitter receptors and transporters in glial cells: single molecule insights
Ciappelloni S, Murphy-Royal C, Dupuis JP, Oliet SHR, Groc L.
Cell Calcium doi: doi.org/10.1016/j.ceca.2017.08.009
Astroglial glutamate transporters in the brain: regulating neurotransmitter homeostasis and synaptic transmission
Murphy-Royal C, Dupuis J, Groc L, Oliet SHR.
Journal of Neuroscience Research doi: doi.org/10.1002/jnr.24029
2015
Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission
Murphy-Royal C, Dupuis JP, Varela JA, Panatier A, Pinson B, Baufreton J, Groc L, Oliet SH.
Nature Neuroscience doi: doi.org/10.1038/nn.3901
News & Views - Mobile binding sites regulate glutamate clearance Link